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Home - Products - Proteasome/Ubiquitin - DUB - LDN 91946

LDN 91946

CAS No. 439946-22-2

LDN 91946( LDN91946 )

Catalog No. M14496 CAS No. 439946-22-2

LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LDN 91946
  • Note
    Research use only, not for human use.
  • Brief Description
    LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM.
  • Description
    LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3).
  • In Vitro
    LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM.
  • In Vivo
    ——
  • Synonyms
    LDN91946
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    439946-22-2
  • Formula Weight
    316.32
  • Molecular Formula
    C17H12N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (265.11 mM)
  • SMILES
    C1(NC2=CC=CN=C2)=NC=C(C3=NC=NC=C3)C(C4=CC=CO4)=N1
  • Chemical Name
    3-amino-2-(benzoyl)-6-oxo-7H-thieno[3,2-e]pyridine-5-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. 2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129.
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